Sonic Hedgehog Induces Floor Plate
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Figure 3 From Gli1 Is A Target Of Sonic Hedgehog That Induces Ventral Neural Tube Development Semantic Scholar
Figure 4 Models For Nodal Action In Floor Plate Induction
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The differentiation of floor plate cells and motor neurons in the vertebrate neural tube appears to be induced by signals from the notochord.
Sonic hedgehog induces floor plate. The differentiation of floor plate cells and motor neurons can be induced by sonic hedgehog shh a secreted signaling protein that undergoes autoproteolytic cleavage to generate amino and carboxy terminal products. The floor plate is a structure integral to the developing nervous system of vertebrate organisms. Induce ectopic medial floor plate cells we conclude that shh is neither required nor sufficient to induce this cell type in the zebrafish. Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions it has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous.
To be the source of a contact dependent factor that induces floor plate differentiation in midline neural plate cells van straaten et al 1988. Sonic hedgehog sonic you zebrafish floor plate somitogenesis summary sonic hedgehogis not required for the induction of medial floor plate cells in the zebrafish. We have found that both floor plate cells and motor neurons are induced by the amino terminal cleavage product of shh shh n. The secreted protein encoded by the sonic hedgehog shh gene is expressed by axial midline cells and can induce floor plate cells in vivo and in vitro.
8 a recent study by. Rons can be induced by sonic hedgehog shh a secreted signaling protein that undergoes autoproteo lytic cleavage to generate amino and carboxy ter. The floor plate of the neural tube is induced by high concentrations of shh n peptide emanating from the notochord jessell 2000. In vitro blocking of shh signaling using.
Sonic hedgehog is both necessary and sufficient to inhibit dorsolateral bending but is neither necessary nor sufficient to induce midline bending which seems likely to be regulated by another notochordal factor. The secreted pro tein encoded by the sonic hedgehog shh gene is expressed by axial midline cells and can induce floor plate cells in vivo and in vitro. Motor neurons can also be induced in vitro by cells that synthesize sonic hedgehog. Sonic hedgehog is the secreted protein which mediates signaling activities of the notochord and floor plate.
Placzek et al 1990 1991 1993. Studies involving ectopic expression of shh in vitro and in vivo result in floor plate induction and differentiation of motor neuron and ventral interneurons on the other hand mice mutant for shh lack ventral spinal cord characteristics. The morphogen sonic hedgehog shh is expressed by the notochord and later by cells of the floor plate where it plays a well described role in determining cell fate in the ventral neural tube. The vertebrate hedgehog related gene sonic hedge hog shh is expressed in ventral domains along the entire rostrocaudal length of the neural tube including the forebrain.
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Figure 1 From Sonic Hedgehog And Wnt Antagonists In Morphogenesis But Collaborators In Axon Guidance Semantic Scholar
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Figure 8 From Distinct Regulators Of Shh Transcription In The Floor Plate And Notochord Indicate Separate Origins For These Tissues In The Mouse Node Semantic Scholar
Wnt Antagonism Of Shh Facilitates Midbrain Floor Plate Neurogenesis Nature Neuroscience
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